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The fellowship code of AGM is LCF/BQ/DI17/11620054. The project that gave rise to these results received the support of a fellowship from “la Caixa” Foundation (ID 1000010434). This work was partially funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the projects MINDS (Proyectos I+D Excelencia + FEDER): TEC2015-70104-P, BIOBOT (Programa Explora Ciencia / Tecnología): TEC2015- 72718-EXP and EuUONANOMED II PCIN-2016-025. JSM has support from the CERCA Programme and by the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya (20). The authors also acknowledge the the foundation Obra Social La Caixa (ID 100010434) and the European Research Council (ERC- StG-757397). įunding: LA and SP thank the Spanish Ministry of Science and Innovation (PID2019-109450RB-I00/AEI /10.13039/501100011033) and the Generalitat de Catalunya through the CERCA program and 206.
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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The data used in this study can be accessed at. Received: FebruAccepted: Published: June 18, 2021Ĭopyright: © 2021 Mares et al. PLoS ONE 16(6):Įditor: José das Neves, University of Porto, PORTUGAL The combination of microfluidic formulation with advanced analysis methods, looking at the single particle level, can improve the understanding of the NP properties, heterogeneities and performance.Ĭitation: Mares AG, Pacassoni G, Marti JS, Pujals S, Albertazzi L (2021) Formulation of tunable size PLGA-PEG nanoparticles for drug delivery using microfluidic technology. Our results show how the microfluidic formulation improves the fine control over the resulting nanoparticles, without compromising any appealing property of PLGA nanoparticle. Finally, we performed in vitro evaluation of obtained NPs using MCF-7 cell line. We also analyzed particle size and encapsulation of fluorescent compounds, using the common bulk analysis and advanced microscopy techniques: Transmission Electron Microscopy and Total Internal Reflection Microscopy, to reveal the heterogeneities occurred in the formulated nanoparticles.
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The particle size tunability and controllability in a hydrodynamic flow focusing device was demonstrated to be greater than in the manual dropwise addition method. Herein, we compared the formulation of PLGA-PEG nanoparticles using the typical manual bulk mixing and a microfluidic chip-assisted nanoprecipitation. Furthermore, a reproducible and controlled formulation supports better predictability of a batch effectiveness in preclinical tests. The control over this step allows us to obtain nanoparticles with tailor-made properties without modification of the co-polymer building blocks. They can be rapidly formulated in a nanoprecipitation process based on self-assembly, resulting in kinetically locked nanostructures. Amphiphilic block co-polymer nanoparticles are interesting candidates for drug delivery as a result of their unique properties such as the size, modularity, biocompatibility and drug loading capacity.